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KMID : 0931320080080020091
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대한상부위장관.헬리코박터학회지
2008 Volume.8 No. 2 p.91 ~ p.96
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The Relationship between Helicobacter pylori Infection and High-sensitivity C-reactive Protein
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Park Tae-Young
Kim Jeong-Wook
Kim Jae-Kyu
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Abstract
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Background/Aims: Since chronic infections are possible risk factor of cardiovascular disease were suggested, many researches about the relationship between inflammatory biomarker and atherosclerosis are progressing. The relationship between Helicobacter pylori infection and high-sensitivity C-reactive protein (hs-CRP), total cholelsterol, triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) was analyzed.
Methods: Forty-eight patients diagnosed with gastric ulcer, duodenal ulcer, gastritis with H. pylori infection on esophagogastroduodenoscopy were enrolled. We analyzed 23 patients (M=17, F=6) followed up hs-CRP.
Results: hs-CRP of 23 patients was decreased from 0.70±0.86 mg/L to 0.64±1.13 mg/L after H. pylori eradication, but there was no statistical significance. hs-CRP of male 17 patients was increased from 0.61±0.52 mg/L to 0.77±1.30 mg/L and hs-CRP of female 6 patients was was decreased from 0.92 ± 1.50 mg/L to 0.31±0.37 mg/L after H. pylori eradication, but there was no statistical significance. There was no statistical significance in total cholelsterol, TG, HDL and LDL.
Conclusions: H. pylori eradication may not have effect on serum hs-CRP, total cholelsterol, TG, HDL and LDL. This study suggests it needs large prospective study to confirm the relationship between H. pylori infection and hs-CRP.
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KEYWORD
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Helicobacter pylori, High-sensitivity C-reactive protein, Atherosclerosis
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